As of the penultimate episode of The Boys Season 3, no. Hughie is still alive. However, he's completely unaware that Temp V is fatal with prolonged use.

Starlight discovers the truth about the dangerous side effects of the 24-hour superpower boost and calls Billy to inform him immediately.

Billy promises Starlight that he'll let Hughie know about the potentially deadly side effects. Starlight's mistake was trusting Billy. He doesn't tell Hughie.

However, it turns out Starlight has actually learned from the past. She doesn't trust Billy to do the right thing at all. Starlight tells Kimiko (Karen Fukuhara) and Frenchie (Tomer Capon) that she's going to save Hughie herself, even though she knows he doesn't want that.

It's hard to imagine Hughie dying in the Season 3 finale of The Boys. After all, the hit satirical superhero series has already been renewed for Season 4. Will the show kill off the guy who has been the central protagonist from the start?

Well, it would be an understatement to say that anything can happen in The Boys.