Spoilers for The Last of Us game below.

Although Henry and Sam form a bond with Joel and Ellie, they don't manage to make it all the way west. Instead, Sam is scratched by an infected as they attempt to escape Pittsburgh, and turns as a result.

Henry kills his brother to save Ellie, and then turns the gun on himself, realizing that he doesn't have anything else to live for. It's a despairing ending for both characters, and it isn't clear how much of that ending will be replicated on the show.