John’s parents are named Alberto and Luz Leguizamo. They welcomed John into the world in Bogata, Colombia. When John was 4 years old, his parents took him along to migrate to the United States where they moved around different neighborhoods in New York City and Queens.

One of the main places they resided in was Jackson Heights. According to The Famous People, his father aspired to be a film director, once upon a time.

By the time John was 14 years old, his parents decided to call it quits and filed for divorce. They didn’t get in the way of his dreams to pursue a career in entertainment, though.

After enrolling at Joseph Pulitzer Middle School and the Murry Bergtraum High School, his parents supported him in starting his theater career at NYU's Tisch School of the Arts. Eventually, he dropped out to start trying his hand at stand-up comedy.