While audiences were hopeful that Dr. Kapoor's Season 3 departure meant he might be able to one day make a return, Season 4 has given viewers closure on the doctor's fate.

As it turns out, the prolific Indian star, who has appeared in over 500 films, stepped away from the medical series in order to care for his wife, Indian theater, film, and TV actress Kirron Kher, who is undergoing treatment for multiple myeloma, a type of blood cancer.

In May 2021, the Bend It Like Beckham actor addressed his New Amsterdam departure on his personal Instagram page. "This past year has been difficult for so many people around the world, not least for Dr. Kapoor," he began. "It was an incredibly special time for me to be part of this show and one I will never forget. The New Amsterdam family will always hold a special place in my heart. I am grateful to the audience for their love, support, and good wishes, particularly for my wife, Kirron, at this time. I hope you all will continue to join me on my journey and future projects."