Here are a number of series that he has featured in throughout his career.
- Gone to Seed - He had the part of Billy for six episodes of this 1992 series.
- Middlemarch - He played Will Ladislaw in all seven episodes of this historical-romance show.
- Screen Two - Rufus appeared twice in this series; once in 1992 as Mike Costain in the episode The Last Romantics and again in 1994 in Dirtysomething as Clive.
- The Last King - Sewell portrayed Charles II on this 2003 mini-series.
- Eleventh Hour - For 18 episodes between 2008 and 2009, Rufus Sewell was the main character, Dr. Jacob Hood, on this crime show.
- The Pillars of the Earth - He played the character, Tom Builder, for seven episodes.
- Zen - The show centered around Rufus Sewell's character, Detective Aurelio Zen.
- Parade's End - He played the role of Reverend Duchemin in three episodes of this mini-series.
- Victoria - From 2016 to 2017, the actor played Lord Melbourne for seven episodes.
- The Marvelous Mrs. Maisel - He was in the episode, Look, She Made a Hat, Declan Howell.
- The Man in the High Castle - From 2015 to 2019, Rufus Sewell played several characters, all named John Smith, in 40 episodes of this sci-fi/thriller show.
- The Pale Horse - The show is in its post-production phase and is set to be released sometime this year. He shall be portraying the character, Mark Easterbrook.
