Russo is a married woman, which sheds some light on her personal life. Dan Gilroy (14 March 1992 – present) is her husband. Since then, they have a daughter, Rose Jean Gilroy, who was born on August 31, 1993. They met on the set of the movie Freejack (1992).
Since then, the couple has been living together and there have been no signs of a divorce. Russo has a sesame allergy. Rene has struggled with bipolar disorder since she was a child. Her sexual orientation is heterosexual.
