Natalie leaves Gaffney Chicago Medical Center after a few failed relationships. So as much as fans hoped she and Will were endgame, by the time she leaves the show, Natalie is single. It isn't necessarily a bad thing, though, because she leaves to be with family.

She steals medicinal drugs for her dying mother, which results in her termination. But before she leaves, Will tells her to keep in touch and promises to find her eventually.

Chicago Med showrunners Andrew Schneider and Diane Frolov told TV Line in September 2021 that Natalie gets a job when she moves to Seattle with her son. Even if that's off-camera, fans can rest easy knowing Natalie has her happy ending. Even if she's single.

"Her career is not damaged," Andrew Schneider said. "Goodwin did not make a big deal; she just let her go. So she goes on. She is going to be fine."

Before Natalie dated fellow doctor Will, she also had a thing with Jeff. But after he stuck up for her in front of other surgeons and made her feel embarrassed, things started to go south. She also dated Crockett for a while, but it didn't work out.

Natalie was married once, but her husband died eight months before the events of the series. Her romances in the show weren't always at the forefront of the drama, but they kept things interesting for the character.