Leonardo DiCaprio playing as Dr. Randall Mindy

Jennifer Lawrence playing as Kate Dibiasky

Meryl Streep playing as President Orlean

Cate Blanchett playing as Brie Evantee

Rob Morgan playing as Dr. Teddy Oglethorpe

Jonah Hill playing as Jason Orlean

Mark Rylance playing as Peter Isherwell

Tyler Perry playing as Jack Bremmer

Timothee Chalamet playing as Yule

Ron Perlman playing as Benedict Drask

Ariana Grande playing as Riley Bina

Kid Cudi playing as DJ Chello

Himesh Patel playing as Phillip

Melanie Lynskey playing as June Mindy

Michael Chiklis playing as Dan Pawketty

Tomer Sisley playing as Adul Grelio

Rafael Silva playing as NASA Scientist

Erik Parillo playing as Sheriff Conlon

Liev Schreiber playing as Bash Narrator

Gary Tanguay playing as News Anchor #2

Georgia Lyman playing as Groomer Thalia

Sarah Silverman playing as Sarah Benterman

Celeste Oliva playing as Nearby Diner

Roman Mitichyan playing as Rioting Patron

Paul Guilfoyle playing as General Themes

Robert Joy playing as Congressman Tenant

Ross Partridge playing as Keith Ollens

Ashleigh Banfield playing as Dalia Hensfield

Jon Glaser playing as Meow Man

Wes Johnson playing as Don’t Look Up’er

Bianca de la Garza playing as Entertainment Journalist

Ishaan Khattar playing as Raghav Manavalan