In 2005, he married the joy of his life, Marianela Orono, whom he met in 2004. They were gifted with twins named Nicola and Dante. In 2004, Marianela gave birth to their third child, Luca.
His family’s lifeblood is basketball, and he grew up observing it. He admired Michael Jordan and desired to emulate him. He speaks Spanish, Italian, and English fluently. Manu Ginobili appreciates listening to Latin music and viewing movies while traveling.