The Season 8 plane crash forever shifts Grey’s Anatomy as fans know it. The crash resulted in the deaths of Mark and Lexie and was responsible for the reason we now call Seattle Grace Grey Sloan Memorial Hospital (though, depending on who you ask, it’s a “his mama named him… situation).

The crash also caused Arizona to lose one of her legs, as it had to be amputated at Callie's orthopedic surgeon’s request. Although Arizona begged Callie to save the leg, she knew amputation, followed by a prosthetic leg, would be best in saving her wife’s life.

The decision causes tension between Callie and Arizona, eventually resulting in Arizona having an affair with Dr. Lauren Boswell (Hilarie Burton). While the affair is brief, Callie discovers it and confronts Arizona. During their argument, Arizona told Callie she would never understand her pain because she wasn’t in the plane crash and didn’t lose anything. Callie then tells Arizona, “Apparently, I lost you.”