OK, so we've established that the reboot is firmly planted in familiarity so far. So what makes it a reboot? Let's start with the obvious. The animation style is different. The first episode actually has the characters acknowledge this in a way that doesn't exactly break the fourth wall, but still makes it clear that even they are aware things are different this time around.
The other most notable update for the reboot? The addition of the power of social media and influencers. Facebook wasn't created until 2004, and social media wasn't nearly as prevalent overall when the original series aired (Oscar still using a flip phone is a nice detail). However, Penny learns about the power of influence in Episode 2. After some of her social media posts go viral, Penny goes a bit power-mad with her ability to cancel people.
Penny even cancels LaCienega after the latter calls her out for it.