Vanderham made her acting debut as Cathy Connor in the six-part crime drama The Runaway on Sky TV, which was based on the Martina Cole novel of the same name. She also had a supporting role in the biographical drama Young James Herriot on BBC One.
In the 2012–2013 seasons of Bill Gallagher’s BBC television series “The Paradise,” which was heavily influenced by Émile Zola’s Au Bonheur des Dames, Vanderham played Denise Lovett. In the film “What Maisie Knew,” starring Julianne Moore and Margo played by Alexander Skarsgard, she made her acting debut.
Vanderham played society girl Pamela Luscombe in the BBC drama Dancing on the Edge, which was directed by Stephen Poliakoff. She made appearances in 2015 as Katherine “Kitty” McVitie in the BBC Two historical drama series “Banished” and Marian Maudsley in the BBC One romantic television movie “The Go-Between.”
Vanderham received a Recognition at the 2016 Ian Charleson Awards for her performance as Queen Anne in Richard III at the London Almeida Theatre. In 2016, Vanderham appeared in the 2016 romantic television film “The Boy with the Topknot” starring Sacha Dhawan.
She played the younger Flora in the two-part drama “Man in an Orange Shirt” and Claire Elliot in the miniseries “One of Us” (also known as Retribution) the following year. In 2019, Vanderham joined the main cast of the American action series “Warrior” playing Penelope Blake.
She played the recurring character Atropos in the fifth season of DC’s Legends of Tomorrow. She portrayed DS Amelia Drummond opposite Dougray Scott in the 2021 BritBox drama “Crime,” which was adapted from the same-titled book by Irvine Welsh.
