The new CBS series is considered to be a sequel epilogue to CSI. The 2021 show takes place in the same lab and it includes several familiar faces from the original drama, but most everything else has changed. CSI wrapped in 2015 after a 15-season run.

The latest addition to the CSI franchise will unite characters from the original show with a new set of forensic criminalists.

Jorja Fox and William Petersen are set to reprise their roles as Gil Grissom and Sara Sidle, respectively, in the 10-episode limited series. Wallace Langham will play technician David Hodges again as well.

Paul Guilfoyle, who had a main role on the drama in the first 14 seasons (and who appeared in a guest capacity on Season 15), will play Jim Brass in two episodes.

Aside from the returning characters and the Vegas setting, star Jorja Fox said that a lot has changed.

"I don't think much is really going to be the same," Jorja shared with E! News. "It's a new day, and we're in new times. I think the show's going to be very reflective of what's happening now."

The new characters on CSI: Vegas include crime lab head Maxine Roby (Paula Newsome) and lead investigator, Josh Folsom (Matt Lauria). Allie Rajan (Mandeep Dhillon) is a Level II crime scene investigator, and Hugo Ramirez (Mel Rodriguez) is the head medical examiner.