Well before 1000-Lb Best Friends, Ashley had bariatric surgery, though she gained her weight back afterward. Meghan Crumpler also had surgery when she appeared on TLC's Too Large, though she too gained some weight back.
Vannessa Cross is the current standard among the ladies, though, since her Season 1 surgery paved the way for her current weight loss.
She continues to work on her health on and off the show. And in many ways, Vannessa may be the biggest source of inspiration for her friends, Tina included.
Watch 1000-Lb Best Friends on Wednesdays at 10 p.m. EST on TLC.