In his personal life, he was married. He then wed Caryn Stephanie Nathanson in 1996 as a result. At the time, Stephanie worked as a supervisor on Saturday Night Live. There are a total of four kids born to the couple. The names of their children are not, however, made public on any social media platform.
The couple, who had been married for almost 20 years, unfortunately separated in 2017. At the unfortunate age of 31, he received a colon cancer diagnosis. After the original surgery, Zucker was able to successfully complete two additional surgeries and chemotherapy. In July 2018 he also took a six-week break from CNN to recover from heart surgery.