The E10 meme is really just a "deez nuts" meme in disguise. The meme typically starts with one person asking another if they are going to E10 later, or some similar question. The person being pranked then responds with an understandable level of confusion, and the person asking the question then responds by saying "E10 deez nuts." If you're still not sure what's going on, you likely haven't noticed that "E10" sounds like "eating."
The joke may not be all that clever, but it has tricked a number of people since it first showed up online. It falls in line with previous versions of the same joke, which included the "Candice" trend that was popular on TikTok in 2021. Often, the joke becomes catching people asking the question, and there's not any actual need for you to provide the answer, at least not online.